We know all of our customers are concerned about COVID-19 (Coronavirus). We want to assure you that we are maintaining normal business hours to meet all of your prescription and over-the-counter needs. We are also sanitizing our counters and credit card area thoroughly throughout the day. We appreciate you supporting your local pharmacy. Thank you!

  • Main Street Pharmacy

    Main Street Pharmacy

    Your Local Health And Wellness Pharmacy

  • Compounding


    Need a special medication? We specialize in custom compounding

  • Free Delivery

    Free Delivery

    Let us come to you

  • Medication Synchronization

    Medication Synchronization

    Pick up all of your medications on the same day each month

  • Pet Care

    Pet Care

    Specialized compounding for your family pet

  • Greeting Cards

    Greeting Cards

    Birthday, Anniversary, or Special Celebration? We've got a card for that!

  • Text Notification Service

    Text Notification Service

    Ask our friendly staff about our text notification service

  • CBD


    Carrying a Full-line of CBD Products!

  • Nurse Practitioner

    Nurse Practitioner

    We have a nurse practitioner on staff to help care for your health needs.

  • Immunizations


    We offer immunizations including the COVID-19 Vaccine and Boosters.

Refill a Prescription

We fill new and existing prescriptions in-store, by phone, online, and with our mobile app.

Refill Now

Transfer a Prescription

Transfer your prescriptions to our pharmacy using our simple and secure online transfer form.

Transfer Now

Contact Us

Visit us in store or get in touch with a member of our pharmacy staff. We're always happy to assist you.

Get in Touch

Your Partners In Health

Main Street Pharmacy Services

Become a Pharmacy Insider

Subscribe to our newsletter for promotions, health news and savings

Our Services

Your One Stop Shop

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Medication Synchronization

Speak to a staff member today about how we can get you set up on med sync.


Easy Prescription Filling

We fill new and existing prescriptions in-store, by phone, online, and with our mobile app.

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Express Delivery

We offer express local delivery and shipping at no cost to you.


Medication Savings

Our pharmacists work with you to coordinate benefits and find financial assistance.

Your Pharmacy Experts

Trust Us With Your Health

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At Main Street Pharmacy, we believe that being a local independent pharmacy means providing healthcare and compounding services to our patients that are customized to meet their needs. Visit us today and let us take care of you.

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Your health information in one place.

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Read Our Patient Reviews


Carla R.

"A true community pharmacy with knowledgeable, caring owners and staff. Customer focused and friendly."


Bill L.

"I am 93 years old, and I have never been treated with so much kindness and compassion that I have received from the staff at Main Street pharmacy in Safety Harbor. They make you feel like you are their only customer"


Taylor B.

"The staff went above and beyond to help me get the right medication (after my doctor’s office sent them the wrong script). They provided excellent customer service and I will certainly be a repeat customer."

Nurse Practitioner

Learn About Us »

Main Street Pharmacy combines high quality products with personalized care. Our staff is happy to help you with any questions you may have.


Explore Our Health News »

Check out our weekly health news blog, or subscribe to our newsletter and receive updates on health articles, promotions, specials and much more.


Find Services »

We offer a wide variety of services including conventional prescription filling, compounding, pet care, medication synchronization and much more.


We'd Love To Hear From You

  • At Main Street Pharmacy, we’re committed to helping you live a healthier life. Our pharmacy staff would be happy to help you with any questions you may have.